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Antigenic Specificity | Human EGFR |
Clone | [SB41a1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry; Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Reacts with human EGFR (150 kDa)1. Epidermal growth factor receptor (EGFR) is a transmembrane receptor for epidermal growth factor (EGF). It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB -1), HER2/c-neu (ErbB-2) Her 3 (ErbB-3 and Her 4 (ErbB-4). EGFR exists on the cell surface as inactive monomers and is activated by binding of its specific ligands, including EGF, transforming growth factor a (TGFa), or others. Upon activation, EGFR can pair with another EGFR to form an active homodimer or an EGFR may pair with another member of the ErbB receptor family, such as Her 2/c-neu, to create a heterodimer. Evidence also suggests that a cluster of active EGFR can form.2-4. The |
Immunogen | Immunogen: Recombinant human EGFR |
Other Names | [Mouse Human EGFR - Purified, Unlabeled; Mouse Human EGFR], [EGFR; EGFR; ERBB; HER1; mENA; ERBB1; PIG61; ERBB1] |
Gene, Accession # | Gene ID: 1956, NCBI: NP_005219.2, UniProt: P00533 |
Catalog # | MBS670104 |
Price | $275 |
Order / More Info | Human EGFR Antibody from MYBIOSOURCE INC. |
Product Specific References | 1) Schlessinger J. (2000)Cell. 103: 13-15.3) Simon MA. (2000) Cell. 103: 3-154) Walk RA. (1998) J. Path. 185: 234-235.5) Woodburn Jr. (1999) Pharmacology and Therapeutics 82: 241-250.6) Raymond E, Faivre S, Armand J. (2000) Drugs. 60 (suppl 1): 15-23.7) Salomon, D, Brandt R, Ciardiello F, et al. (1995) Critical Reviews in Oncology/Haematology. 19: 183-232.8) Sedlacek HH. (2000) Drugs.59: 435-576. |