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Antigenic Specificity | DFFA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | 100ug/100ul |
Applications | Peptide ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DFFA antibody detects endogenous levels of DFFA protein. Not tested with other proteins. Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromat |
Immunogen | Immunogen: Synthetic peptide conjugated to KLH |
Other Names | [DNA fragmentation factor subunit alpha isoform 2; DNA fragmentation factor subunit alpha; DNA fragmentation factor subunit alpha; DFF45; DNA fragmentation factor 45 kDa subunit; inhibitor of CAD; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor 45 kDa subunit; DFF-45; Inhibitor of CAD; ICAD], [DFFA; DFFA; DFF1; ICAD; DFF-45] |
Gene, Accession # | [DFFA], Gene ID: 1676, NCBI: NP_998731.1 |
Catalog # | MBS416354 |
Price | $230 |
Order / More Info | DFFA Antibody from MYBIOSOURCE INC. |
Product Specific References | Liu,X., Zou,H., Slaughter,C et,al DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis |