Piccolo Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Piccolo |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | ATTO 633 conjugate |
| Size | 0.1 mg |
| Concentration | 1mg/mL |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Background Info: Detects ~550kDa corresponding to the molecular weight of Piccolo. Multiple isoforms can be detected. No cross-reactivity to Bassoon. Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2 finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2). |
| Immunogen | n/a |
| Other Names | [ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo (presynaptic cytomatrix protein); Piccolo mouse homolog of Pico; Presynaptic cytomatrix protein; Protein piccolo], [PCLO; PCLO; ACZ; ACZ; KIAA0559] |
| Gene, Accession # | Gene ID: 27445, NCBI: NP_055325.2, UniProt: Q9Y6VO |
| Catalog # | MBS805175 |
| Price | $440 |
| Order / More Info | Piccolo Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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