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Antigenic Specificity | FZD5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differen |
Immunogen | Immunogen: Fusion protein of FZD5 Calculated Molecular Weight: 585aa; 65kd Observed MW: 65kD |
Other Names | [C2orf31; DKFZp434E2135; HFZ5; MGC129692] |
Gene, Accession # | [FZD5], Gene ID: 7855, NCBI: NP_003459.2 |
Catalog # | MBS2520484 |
Price | $195, $270, $435 |
Order / More Info | FZD5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |