PARK7 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | PARK7 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Parkinson's disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in alpha-synuclein, Parkin, and DJ-1 are linked to PD (1). alpha-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD (1). Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator |
| Immunogen | Immunogen: Recombinant protein of human PARK7 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [PARK7; DJ-1; DJ1; FLJ27376; FLJ34360; FLJ92274] |
| Gene, Accession # | [PARK7], Gene ID: 11315, NCBI: NP_001116849.1, UniProt: Q99497 |
| Catalog # | MBS8504364 |
| Price | $310 |
| Order / More Info | PARK7 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Borrelli, E. (2005) Neuron 45, 479-81. 2. Bonifati, V. et al. (2003) Science 299, 256-9. 3. Nagakubo, D. et al. (1997) Biochem. Biophys. Res. Commun. 231, 509-13. 4. Takahashi, K. et al. (2001) J. Biol. Chem. 276, 37556-63. 5. Mitsumoto, A. and Nakagawa, Y. (2001) Free Radic. Res. 35, 885-93. 6. Goldberg, M.S. et al. (2005) Neuron 45, 489-96. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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