N Myc Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | N Myc |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: N Myc antibody detects endogenous levels of total N Myc. Description: Note=Amplification of the N-MYC gene is associated with a variety of human tumors, most frequently neuroblastoma, where the level of amplification appears to increase as the tumor progresses.Function: Positively regulates the transcription of MYCNOS in neuroblastoma cells.Subunit Structure: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with KDM5A, KDM5B and HUWE1. Interacts with MYCNOS. Interacts with AURKA; interaction is phospho-independent and triggers AURKA activation; AURKA competes with FBXW7 for binding to unphosphorylated MYCN but not for binding to unphosphorylated MYCN ( |
| Immunogen | Immunogen: A synthesized peptide derived from human N Myc Subcellular Location: Nucleus. Tissue Specificity: Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). Predicted Cross Reactivity: Pig, Bovine, Sheep, Chicken Similarity: Pig (100%), Bovine (100%), Sheep (100%), Chicken (83%) |
| Other Names | [bHLHe37; Class E basic helix-loop-helix protein 37; MODED; mycn; MYCN_HUMAN; N myc; N myc proto oncogene protein; N-myc proto-oncogene protein; Neuroblastoma derived v myc avian myelocytomatosis viral related oncogene; Neuroblastoma MYC oncogene; NMYC; NMYC proto oncogene protein; ODED; Oncogene NMYC; pp65/67; V myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog; v myc avian myelocytomatosis viral related oncogene neuroblastoma derived; v myc myelocytomatosis viral related oncogene neuroblastoma derived] |
| Gene, Accession # | [MYCN], Gene ID: 4613, NCBI: NP_001280157.1, UniProt: P04198 |
| Catalog # | MBS9601377 |
| Price | $240, $280 |
| Order / More Info | N Myc Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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