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Antigenic Specificity | ITGB6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: ITGB6 antibody detects endogenous levels of total ITGB6. Function: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881).Subunit Structure: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. ITGAV:ITGB6 interacts with FBN1 (PubMed:17158881).Similarity: Belongs to the integrin beta chain family. |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Membrane. Predicted Cross Reactivity: Pig, Horse, Rabbit, Dog Similarity: Pig (89%), Horse (89%), Rabbit (89%), Dog (89%) |
Other Names | [Integrin beta-6; ITB6_HUMAN; ITGB6] |
Gene, Accession # | [ITGB6], Gene ID: 3694, NCBI: NP_000879.2, UniProt: P18564 |
Catalog # | MBS9604057 |
Price | $240, $280 |
Order / More Info | ITGB6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |