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Antigenic Specificity | Aposcreen Annexin V-PE |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 100 tests |
Concentration | n/a |
Applications | Blocking Annexin V-conjugates, Flow Cytometry, Fluorescence Microscopy |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | A number of changes in cell structure occur during apoptosis. One major change is the loss of membrane phospholipid asymmetry, with translocation of phosphatidylserine (PS) from the inner leaflet of the phospholipid bilayer to the external surface.1 Annexin V (Mr 36-kDa), a member of the annexin family of calcium-dependent phospholipid binding proteins, has a high affinity for PS-containing phospholipid bilayers.2,3 When PS is exposed on the extracellular face of a cell membrane, annexin V binds with an affinity of approximately 7 nM.4 Fluorochrome conjugates of annexin V can be used to monitor changes in cell membrane phospholipid asymmetry,5-8 thereby providing a convenient tool for detection of apoptotic cells. ApoScreen Annexin V is a l |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS670377 |
Price | $250 |
Order / More Info | Aposcreen Annexin V-PE Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Fadok, V.A. et al. 1992. J. Immunol. 148:22072. Tait, J.F., et al. 1989. J. Biol. Chem. 264:7944.3. Andree, H.A., et al. 1990. J. Biol. Chem. 265:4923.4. Thiagarajan, P., et al. 1990. J. Biol. Chem. 265:17420.5. Dachary, P.J., et al. 1993. Blood 81:2554.6. Koopman, G., et al. 1994. Blood 84:1415.7. Martin, S.J., et al. 1995. J. Exp. Med. 182:1545.8. Wood, B.L., et al. 1996. Blood 88:1873. |