Edit |   |
---|---|
Antigenic Specificity | SQSTM1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | SQSTM1 Antibody: SQSTM1/p62 is an adapter protein which binds ubiquitin and regulates signaling cascades through ubiquitination. It may regulate the activation of NF-κB by TNF-α, nerve growth factor (NGF) and interleukin-1. SQSTM1/p62, a co-interacting protein of the atypical PKC isoforms, has a UBA domain at its C-terminal end, which binds non-covalently to polyubiquitin chain. SQSTM1's UBA domain is necessary for recruitment of polyubiquitin and aggresome formation. SQSTM1 may play a role in titin/TTN downstream signaling in muscle cells and may be involved in cell differentiation, apoptosis, immune response and regulation of K+ channels. Mutations in the ubiquitin-associated (UBA) domain of SQSTM1 commonly cause Paget's disease |
Immunogen | Immunogen: SQSTM1 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human SQSTM1. Buffer: SQSTM1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [SQSTM1; p60; p62; A170; OSIL; PDB3; ZIP3; p62B; ORCA; Sequestosome-1; EBI3-associated protein of 60 kDa; EBIAP; sequestosome 1], [SQSTM1; SQSTM1; p60; p62; A170; OSIL; PDB3; ZIP3; p62B; ORCA; OSIL; EBIAP; p60] |
Gene, Accession # | [SQSTM1], Gene ID: 8878, NCBI: Q13501.1, UniProt: Q13501 |
Catalog # | MBS151473 |
Price | $375 |
Order / More Info | SQSTM1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |