Mouse CD152 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse CD152 |
| Clone | [1B8] |
| Host Species | Hamster |
| Reactive Species | n/a |
| Isotype | IgG |
| Format | unconjugated |
| Size | 0.25 mg |
| Concentration | IgG concentration 1.0mg/ml |
| Applications | ELISA (EIA), Flow cytometry (FC/FACS), Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Hamster anti Mouse CD152 antibody, clone 1B8 recognizes mouse CD152, commonly known as CTLA-4 (cytotoxic T-lymphocyte protein 4), a structural homolog for CD28. CD152 binds the same ligands as CD28, namely CD80 (B7.1) and CD86 (B7.2), but with much higher affinity. However, while binding of CD28 enhances T cell function, binding of CD152 inhibits it. CD152 is not detected on na?ve T-cells and is induced upon T-cell activation. In mice, lack of CD152 leads to massive lymphoproliferative disorder leading to tissue destruction and autoimmunity, suggesting a critical role for CD152 in limiting T-cell responses. CD152 has been shown to reduce IL-2 production after ligation and can inhibit T-cell expansion. This regulatory role and the high bindi |
| Immunogen | Immunogen: Extracellular portion of mouse CD152 fused to a mouse IgG2a. Fusion Partners: Lymph cells from immunised Armenian hamsters were fused with cells of the murine SP2/0 myeloma cell line. Buffer Solution: Phosphate buffered saline Target Species: Mouse |
| Other Names | [cytotoxic T-lymphocyte protein 4 isoform 1; Cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte protein 4; CD152 antigen; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD_antigen: CD152], [Ctla4; Ctla4; Cd152; Ly-56; Ctla-4; Cd152; CTLA-4] |
| Gene, Accession # | [CD152], Gene ID: 12477, NCBI: NP_033973.2, UniProt: P09793 |
| Catalog # | MBS219504 |
| Price | $430 |
| Order / More Info | Mouse CD152 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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