Cortactin Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCortactin
Clone[401CT8.6.3]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgM
Formatascites
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), ELISA (EIA)
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DescriptionSpecificity: Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody. This gene is overexpressed in breast cancer and squamouscell carcinomas of the head and neck. The encoded protein islocalized in the cytoplasm and in areas of the cell-substratumcontacts. This gene has two roles: (1) regulating the interactionsbetween components of adherens-type junctions and (2) organizingthe cytoskeleton and cell adhesion structures of epithelia andcarcinoma cells. During apoptosis, the encoded protein is degradedin a caspase-dependent manner. The aberrant regulation of this genecontributes to tumor cell invasion and metastasis. Three splicevariants that encode different isoforms
Immunogenn/a
Other Names[Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN; EMS1]
Gene, Accession #[CTTN], Gene ID: 2017, NCBI: NP_001171669.1, UniProt: Q14247
Catalog #MBS9200474
Price$370
Order / More InfoCortactin Antibody from MYBIOSOURCE INC.
Product Specific ReferencesCroucher, D.R., et al. Mol. Cell. Biol. 30(21):5057-5070(2010) Eiseler, T., et al. J. Biol. Chem. 285(24):18672-18683(2010) Xu, X.Z., et al. Mod. Pathol. 23(2):187-196(2010) Saitoh, Y., et al. Int. J. Oncol. 35(6):1277-1288(2009) Hirakawa, H., et al. Int. J. Oncol. 35(6):1271-1276(2009)
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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