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Antigenic Specificity | Cortactin |
Clone | [401CT8.6.3] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgM |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Purified His-tagged Cortactin protein(Fragment) was used to produced this monoclonal antibody. This gene is overexpressed in breast cancer and squamouscell carcinomas of the head and neck. The encoded protein islocalized in the cytoplasm and in areas of the cell-substratumcontacts. This gene has two roles: (1) regulating the interactionsbetween components of adherens-type junctions and (2) organizingthe cytoskeleton and cell adhesion structures of epithelia andcarcinoma cells. During apoptosis, the encoded protein is degradedin a caspase-dependent manner. The aberrant regulation of this genecontributes to tumor cell invasion and metastasis. Three splicevariants that encode different isoforms |
Immunogen | n/a |
Other Names | [Src substrate cortactin; Amplaxin; Oncogene EMS1; CTTN; EMS1] |
Gene, Accession # | [CTTN], Gene ID: 2017, NCBI: NP_001171669.1, UniProt: Q14247 |
Catalog # | MBS9200474 |
Price | $370 |
Order / More Info | Cortactin Antibody from MYBIOSOURCE INC. |
Product Specific References | Croucher, D.R., et al. Mol. Cell. Biol. 30(21):5057-5070(2010) Eiseler, T., et al. J. Biol. Chem. 285(24):18672-18683(2010) Xu, X.Z., et al. Mod. Pathol. 23(2):187-196(2010) Saitoh, Y., et al. Int. J. Oncol. 35(6):1277-1288(2009) Hirakawa, H., et al. Int. J. Oncol. 35(6):1271-1276(2009) |