HUWE1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | HUWE1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.05 mg |
| Concentration | Total protein concentration 1.0mg/ml |
| Applications | Immunohistology Paraffin, Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This item specifically recognises human HUWE1, a 148kDa DNA binding protein. . HUWE1 is a novel E3 ubiquitin-protein ligase involved with mediating ubiquitination and subsequent proteasomal degradation of target proteins.. HUWE1 is involved in apoptosis through catalyzation of the polyubiquitination and degradation of MCL1, ubiquitination of the p53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Research indicates that HUWE1 regulates the abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation. MBS223881 specifically recognises human HUWE1, a 148kDa DNA binding protein. HUWE1 is a novel E3 ubiquitin-protein l |
| Immunogen | Immunogen: A synthetic peptide corresponding to an 19 amino acid sequence from near the carboxy terminal of human HUWE1. Histology Positive Control Tissue: Human brain (cortex) or human heart Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antiserum to human HUWE1 was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human |
| Other Names | [E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase HUWE1; ARF-binding protein 1; BJ-HCC-24 tumor antigen; HECT domain protein LASU1; Mcl-1 ubiquitin ligase E3; URE-binding protein 1; homologous to E6AP carboxyl terminus homologous protein 9; large structure of UREB1; upstream regulatory element-binding protein 1; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase; ARF-binding protein 1; ARF-BP1; HECT, UBA and WWE domain-containing protein 1; Homologous to E6AP carboxyl terminus homologous protein 9; HectH9; Large structure of UREB1; LASU1; Mcl-1 ubiquitin ligase E3; Mule; Upstream regulatory element-binding protein 1; URE-B1; URE-binding protein 1], [HUWE1; HUWE1; MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272; KIAA0312; KIAA1578; UREB1; ARF-BP1; HectH9; LASU1; Mule; URE-B1; URE-binding protein 1] |
| Gene, Accession # | [HUWE1], Gene ID: 10075, NCBI: NP_113584.3, UniProt: Q7Z6Z7 |
| Catalog # | MBS223881 |
| Price | $630 |
| Order / More Info | HUWE1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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