Phospho-KSR1 (Ser392/406) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-KSR1 (Ser392/406) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-KSR1 (Ser392/406) antibody detects endogenous levels of KSR1. Function: Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.Subunit Structure: Interacts with HSP90AA1/HSP90, YWHAE/14-3-3, CDC37, MAP2K1/MEK-1 and MAP2K2/MEK-2 (PubMed:10409742). Interacts with MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization (By similarity). Interacts with isoform 1 of VRK2 (PubMed:2 |
| Immunogen | Immunogen: A synthesized peptide derived from human KSR1 around the phosphorylation site of Ser392/406. Subcellular Location: Endoplasmic Reticulum; Plasma Membrane Predicted Cross Reactivity: Pig, Bovine, Rabbit, Dog, Chicken Similarity: Pig (100%), Bovine (100%), Rabbit (100%), Dog (100%), Chicken (92%) |
| Other Names | [BKSR 1; BKSR1; dKsr; EK 31; EK31; hb; Kinase suppressor of Ras 1; Kinase suppressor of ras; KSR 1; KSR; KSR1; KSR1_HUMAN; Positive Ras signaling mediator family member (86.4 kD); Positive Ras signaling mediator family member; RSU 2; RSU2; SR 31; SR31; Suppressor of activated let 60 Ras SUR3; Suppressor of Ras1 31] |
| Gene, Accession # | [KSR1], Gene ID: 8844, NCBI: NP_055053.1, UniProt: Q8IVT5 |
| Catalog # | MBS9600686 |
| Price | $240, $280 |
| Order / More Info | Phospho-KSR1 (Ser392/406) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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