COX-1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-COX-1 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | COX-1 |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunocytochemistry (ICC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to near C-terminal residues of COX-1. Cyclooxygenase-1(Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid. Cox1 is expressed constitutively in most tissues, while Cox2 expression is induced by lipopolysaccaride (LPS) and peptoglycan (PGN). PGN activates Ras, leading to phosphorylation of Raf at Ser338 and Erk 1/2 at Tyr204). Both Cox1 and Cox2 play a role in the neuropathology of Alzheimer's disease by potentiating gamma-secretase activity and beta-amyloid generation. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. |
| Immunogen | n/a |
| Other Names | [prostaglandin G/H synthase 1 isoform 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase 1; prostaglandin-endoperoxide synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1], [PTGS1; PTGS1; COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1; COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1] |
| Gene, Accession # | [COX-1], Gene ID: 5742, NCBI: NP_000953.2, UniProt: P23219 |
| Catalog # | MBS857192 |
| Price | $280 |
| Order / More Info | COX-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Sakamoto C. Roles of COX-1 and COX-2 in gastrointestinal pathophysiology. J Gastroenterol, 1998, 33(5)?618 2. Lee C, Chen KW, Sheu FS, et al. Studies of a tumor-associated antigen, COX-1, recognized by a monoclonal antibody. Cancer Immunol Immunother, 1992, 35(1)?19 3. Takahashi Y., Ueda N., et al.; Immunoaffinity purification and cDNA cloning of human platelet prostaglandin endoperoxide synthase (cyclooxygenase).; Biochem. Biophys. Res. Commun. 182:433-438(1992). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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