Edit |   |
---|---|
Antigenic Specificity | Human Platelet Factor 4 |
Clone | [RTO] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2bkappa |
Format | biotin conjugate |
Size | 0.1 mg |
Concentration | 0.1 mg/ml |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is specific for Human Platelet Factor IV. Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. (clone RTO) is seen to bind free PF4 in the absence of any bound heparin. This is unlike (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced T |
Immunogen | Immunogen: Human Factor IV purified from the supernatant of thrombin activated platelets. |
Other Names | [Platelet Factor 4, Biotin (Clone: RTO) (Mouse IgG2b); Human Platelet Factor IV], [PF4V1; PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1; CXCL4V1; SCYB4V1] |
Gene, Accession # | Gene ID: 5197, NCBI: AAA60067.1, UniProt: P10720 |
Catalog # | MBS520471 |
Price | $325 |
Order / More Info | Human Platelet Factor 4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |