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Antigenic Specificity | SMARCA4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also bin |
Immunogen | Immunogen: Recombinant human Transcription activator BRG1 protein (808-1092AA) |
Other Names | [Transcription activator BRG1; ATP-dependent helicase SMARCA4; BRG1-associated factor 190A; BAF190A; Mitotic growth and transcription activator; Prote; SMARCA4; BAF190A; BRG1; SNF2B; SNF2L4] |
Gene, Accession # | [SMARCA4], Gene ID: 6597, NCBI: NP_001122316.1, UniProt: P51532 |
Catalog # | MBS7044090 |
Price | $160, $235 |
Order / More Info | SMARCA4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |