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Antigenic Specificity | AXL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Axl, Sky and Mer are three members of a receptor tyrosine kinase (RTK) family that share a conserved intracellular tyrosine kinase domain and an extracellular domain similar to those seen in cell adhesion molecules. These RTKs bind the vitamin K-dependent protein growth-arrest-specific 6 (Gas6), which is structurally related to the protein S anticoagulation factor (1). Upon binding to its receptor, Gas6 activates phosphatidylinositol 3-kinase (PI3K) and its downstream targets Akt and S6K, as well as NF-kappaB (2,3). A large body of evidence supports a role for Gas6/Axl signaling in cell growth and survival in normal and cancer cells (4). |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [Axl: AXL; JTK11; UFO], [AXL; AXL; ARK; UFO; JTK11; Tyro7; UFO] |
Gene, Accession # | [AXL], Gene ID: 558, NCBI: P30530.3, UniProt: P30530 |
Catalog # | MBS125146 |
Price | $275, $430 |
Order / More Info | AXL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |