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Antigenic Specificity | Epo-R (Ab-426) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Epo-R protein. Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase.Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.Winkelmann J.C., Blood 76:24-30(1990) [PubMed: 2163695].Jones S.S.,Blood 76:31-35(1990) [PubMed: 2163696].Noguchi C.T., Blood 78:2548-2556(1991) [PubMed: 1668606]. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from Internal of human Epo-R. |
Other Names | [Erythropoietin receptor; EPO-R] |
Gene, Accession # | [Epo-R], Gene ID: 2057, NCBI: NP_000112.1, UniProt: P19235 |
Catalog # | MBS9412673 |
Price | $200, $255 |
Order / More Info | Epo-R (Ab-426) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |