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Antigenic Specificity | (Mouse) Bmi1 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mouse Bmi1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-268 amino acids from the C-terminal region of mouse Bmi1. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity). |
Immunogen | n/a |
Other Names | [Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; Bmi1; Bmi-1; Pcgf4] |
Gene, Accession # | [Bmi1], Gene ID: 12151, NCBI: NP_031578.2, UniProt: P25916 |
Catalog # | MBS9208023 |
Price | $150 |
Order / More Info | (Mouse) Bmi1 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Haupt Y.,et al.Cell 65:753-763(1991). van Lohuiizen M.,et al.Cell 65:737-752(1991). Cao R.,et al.Mol. Cell 20:845-854(2005). Buchwald G.,et al.EMBO J. 25:2465-2474(2006). |