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Antigenic Specificity | Human MCAM |
Clone | [4H55] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Melanoma Cell Adhesion Molecule (MCAM)/CD146 is a surface antigen on metastatic human melanoma cells originally called MUC18 or A32. The 113 kDa glycoprotein is a member of the immunoglobulin superfamily that shows significant homology to several cell adhesion molecules, notably N-CAM. MCAM/CD146 is also identical to the endothelial cell antigen S-Endo. In addition to melanoma and endothelial cells, MCAM/CD146 is expressed on smooth muscle cells, cerebellar cortex, trophoblasts and activated T cells. MCAM/CD146 is also expressed on a variety of malignant cell types including: vascular and smooth muscle tumors gliomas and neuroblastomas, prostate tumors, and in tumors arising from hematologic malignancies. As a proposed adhesion receptor, MC |
Immunogen | Antibody Generation: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of MCAM (also called CD146). |
Other Names | [MCAM; CD146; MUC18], [MCAM; MCAM; CD146; MUC18; MUC18] |
Gene, Accession # | [MCAM], Gene ID: 4162, NCBI: NP_006491.2, UniProt: P43121 |
Catalog # | MBS690159 |
Price | $490 |
Order / More Info | Human MCAM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |