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Antigenic Specificity | EYA1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similar |
Immunogen | Immunogen: Recombinant Human Eyes absent homolog 1 protein (168-321AA) |
Other Names | [Eyes absent homolog 1; EYA1] |
Gene, Accession # | [EYA1], Gene ID: 2138, NCBI: NP_000494.2, UniProt: Q99502 |
Catalog # | MBS7107527 |
Price | $160, $235 |
Order / More Info | EYA1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |