GRB10 (N-term), 1-30 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | GRB10 (N-term), 1-30 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.49 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This GRB10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human GRB10. Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine |
| Immunogen | n/a |
| Other Names | [Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR; GRB10; GRBIR; KIAA0207] |
| Gene, Accession # | [GRB10], Gene ID: 2887, NCBI: NP_001001549.1, UniProt: Q13322 |
| Catalog # | MBS9204511 |
| Price | $165, $370 |
| Order / More Info | GRB10 (N-term), 1-30 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Liu F., et al. Proc. Natl. Acad. Sci. U.S.A. 92:10287-10291(1995). O'Neill T.J., et al. J. Biol. Chem. 271:22506-22513(1996). Frantz J.D., et al. J. Biol. Chem. 272:2659-2667(1997). Dong L.Q., et al. J. Biol. Chem. 272:29104-29112(1997). Nantel A., et al. J. Biol. Chem. 273:10475-10484(1998). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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