SETD7/Set7 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | SETD7/Set7 |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. |
| Immunogen | Immunogen: A synthesized peptide derived from human SETD7. Subcellular Localization: Nucleus. Chromosome. Tissue Specificity: Widely expressed. Expressed in pancreatic islets. |
| Other Names | [Histone-lysine N-methyltransferase SETD7; 2.1.1.43; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; Lysine N-methyltransferase 7; SET domain-containing protein 7; SET7/9; SETD7; KIAA1717; KMT7; SET7; SET9], [SETD7; SETD7; KMT7; SET7; SET9; SET7/9; KIAA1717; KMT7; SET7; SET9; H3-K4-HMTase SETD7] |
| Gene, Accession # | [SETD7], Gene ID: 80854, NCBI: NP_001293128.1, UniProt: Q8WTS6 |
| Catalog # | MBS179893 |
| Price | $160, $340, $340 |
| Order / More Info | SETD7/Set7 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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