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Antigenic Specificity | LRP-5 / 6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg |
Concentration | 0.5 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta-catenin stabilization. |
Immunogen | Immunogen: Synthetic peptide surrounding amino acid 437 of human LRP |
Other Names | [LRP-5; LRP -6], [LRP5; LRP5; HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; OPTA1; VBCH2; LR3; LRP7; LRP-5] |
Gene, Accession # | [LRP-5/6], Gene ID: 4041, NCBI: NP_001278831.1, UniProt: O75197 |
Catalog # | MBS841021 |
Price | $150, $290 |
Order / More Info | LRP-5 / 6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |