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Antigenic Specificity | CUL4A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histo |
Immunogen | Immunogen: Recombinant Human Cullin-4A protein (1-61AA) Conjugation: Non-conjugated |
Other Names | [Cullin-4A; CUL-4A; CUL4A] |
Gene, Accession # | [CUL4A], Gene ID: 8451, NCBI: NP_001008895.1, UniProt: Q13619 |
Catalog # | MBS7052825 |
Price | $160, $235 |
Order / More Info | CUL4A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |