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Antigenic Specificity | CIS-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~29 kDa of CIS-1 protein from human, rat and mouse origins. The other species are not tested. Cytokines induce a variety of biological responses by binding to specific cell surface receptors and activating cytoplasmic signal transduction pathways which are suppressed by other transcriptional factors. Proteins that mediate these signals from the cell surface to the nucleus include JAKs and STATs, while SOCS (Suppressor of cytokine signaling) proteins inhibit those signaling. The SOCS family comprises at least 8 members, SOCS1 to SOCS7 and CIS (cytokine inducible SH2 containing protein). Structurally, the SOCS proteins are composed of an N terminal region of variable length and amino acid composition, a central SH2 do |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to internal sequence of CIS-1 protein from human, rat and mouse origins. |
Other Names | n/a |
Gene, Accession # | [CIS-1] |
Catalog # | MBS462186 |
Price | $285 |
Order / More Info | CIS-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Aman,M.J et al. CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling. J. Biol. Chem. 274 (42), 30266-30272 (1999). |