Metadherin Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Metadherin |
| Clone | [2F11C3] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Metadherin is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis. |
| Immunogen | Immunogen: Metadherin antibody was raised in Mouse using a purified recombinant fragment of human MTDH expressed in E Coli as the immunogen. |
| Other Names | [Mouse Metadherin; Metadherin; Metadherin; Metastasis adhesion protein; MTDH; LYsine-RIch CEACAM1 co-isolated; LYRIC; Metadherin; Metadherin; Metastasis adhesion protein; MTDH; LYsine-RIch CEACAM1 co-isolated; LYRIC] |
| Gene, Accession # | [MTDH], Gene ID: 92140, NCBI: AAH45642.1 |
| Catalog # | MBS5310884 |
| Price | $430 |
| Order / More Info | Metadherin Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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