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Antigenic Specificity | IRAK-4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: IRAK-4 antibody is predicted to not cross-react with other members of the IRAK protein family. IRAK-4 Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular responses through IL-1 receptor (IL-1R) and Toll-like receptors (TLR). IL-1R-associated kinases (IRAK, IRAK2, and IRAK-M) regulate the activation of NF-κB and MAP kinase (MAPK) by IL-1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-4. Overexpression of IRAK-4 activates NF-κB and MAPK pathways. IRAK-4 interacts with and phosphorylates IRAK-1. IRAK-4-deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK-4 are impaired in their responses to viral and bacte |
Immunogen | Immunogen: IRAK-4 antibody was raised against a synthetic peptide corresponding to 13 amino acids near the carboxy terminus of human IRAK-4. Buffer: IRAK-4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [IRAK-4; IPD1; REN64; IRAK-4; NY-REN-64; Interleukin-1 receptor-associated kinase 4; Renal carcinoma antigen NY-REN-64; interleukin-1 receptor-associated kinase 4], [IRAK4; IRAK4; IPD1; REN64; IRAK-4; NY-REN-64; IRAK-4] |
Gene, Accession # | [IRAK4], Gene ID: 51135, NCBI: AAM15772, UniProt: Q9NWZ3 |
Catalog # | MBS151320 |
Price | $375 |
Order / More Info | IRAK-4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |