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Antigenic Specificity | COP9 signalosome complex subunit 7a |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total COP9 signalosome complex subunit 7a polyclonal antibody. Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, r |
Immunogen | Immunogen: Recombinant Human COP9 signalosome complex subunit 7a protein (2-275aa) |
Other Names | [SGN7a; Signalosome subunit 7a; Dermal papilla-derived protein 10; JAB1-containing signalosome subunit 7a; COPS7A; CSN7A; DERP10] |
Gene, Accession # | Gene ID: 50813, NCBI: NP_001157565.1, UniProt: Q9UBW8 |
Catalog # | MBS9416430 |
Price | $320 |
Order / More Info | COP9 signalosome complex subunit 7a Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |