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Antigenic Specificity | DES |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (PubMed:25358400). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures (PubMed:24200904, PubMed:25394388, PubMed:26724190). May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckle |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 121-470 of human DES (NP 001918.3). |
Other Names | [CSM1; CSM2; CDCD3; CMD1F; LGMD1D; LGMD1E; LGMD2R] |
Gene, Accession # | [DES], Gene ID: 1674, NCBI: NP_001918.3, UniProt: P17661 |
Catalog # | MBS8544095 |
Price | $280 |
Order / More Info | DES Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |