RWDD3 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | RWDD3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases IkBeta sumoylation and stability. In addition, RWDD3 inhibits TNF-a-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of IkBeta increased stability. RSUME-enhanced sumoylation of IkBeta leads to the inhibition of NF-kBeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiti |
| Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 17 amino acid peptide from near the amino terminus of human RWDD3. |
| Other Names | [RWD domain containing 3, RSUME, RWD-containing sumoylation enhancer] |
| Gene, Accession # | [RWDD3], Gene ID: 25950, NCBI: NP_056300 |
| Catalog # | MBS9402956 |
| Price | $320 |
| Order / More Info | RWDD3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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