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Antigenic Specificity | CD71, Mouse |
Clone | ER-MP21 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | F, Flow Cytometry (FC/FACS), FS, P |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody ER-MP21 recognizes CD71, the transferrin receptor 1. CD71 is a 200 kDa glycoprotein composed of two identical, disulfide-linked chains. Each chain is capable of binding transferrin, an iron-transport molecule. Binding of transferrin to its receptor followed by endocytosis of the receptor-ligand complex is a major cellular iron-uptake mechanism. Iron uptake by the proliferating cell is essential for the iron-containing enzyme ribonucleotide reductase involved with DNA synthesis. CD71 is not only expressed by cycling cells, but also by cells that require iron for other iron-dependent proteins, such as the enzyme peroxidase in monocytes. Rapidly proliferating cells, as in malignancy, generally expre |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | [CD71] |
Catalog # | MBS584096 |
Price | $420 |
Order / More Info | CD71, Mouse Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Leenen, P et al; Differential inhibition of macrophage proliferation by anti-transferrin receptor antibody ER-MP21: correlation to macrophage differentiation stage. Exp Cell Res 1990, 189: 55 2. Brekelmans, P et al; Transferrin receptor expression as a marker of immature cycling thymocytes in the mouse. Cell Immunol 1994, 159: 331 3. Brekelmans, P et al; Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody. Eur J Immunol 1994, 24: 2896 |