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Antigenic Specificity | Notch 1 (Cleaved-Val1744) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Notch 1 (Cleaved-Val1744) antibody detects endogenous levels of total Notch 1 (Cleaved-Val1744). Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and poss |
Immunogen | Immunogen: A synthesized peptide derived from human Notch 1 (Cleaved-Val1744) Subcellular Location: Cell Membrane and Nucleus. Following proteolytical processing NICD is translocated to the nucleus. Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. Predicted Cross Reactivity: Pig, Bovine, Horse, Dog Similarity: Pig (100%), Bovine (100%), Horse (100%), Dog (100%) |
Other Names | [9930111A19Rik; AOS5; AOVD1; hN1; Lin-12; LIN12; Mis6; Motch A; mT14; Neurogenic locus notch homolog protein 1; Neurogenic locus notch protein homolog; NICD; NOTC1_HUMAN; Notch 1; Notch 1 intracellular domain; NOTCH; Notch gene homolog 1 (Drosophila); Notch homolog 1, translocation-associated (Drosophila); NOTCH, Drosophila, homolog of, 1; notch1; TAN1; Translocation associated notch homolog; Translocation associated notch protein TAN 1; Translocation-associated notch protein TAN-1; xotch] |
Gene, Accession # | [NOTCH1], Gene ID: 4851, NCBI: NP_060087.3, UniProt: P46531 |
Catalog # | MBS9601479 |
Price | $240, $280 |
Order / More Info | Notch 1 (Cleaved-Val1744) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |