Description | Specificity: CD23 low affinity IgE Fc receptor. The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments.^1 It is expressed on most mature, conventional B cells (but not on peritoneal CD5^+ B cells), and can also be found on the surface of T cells, macrophages and platelets.^1-6 It is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation.^3 The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors.^2-6 CD23 has been describ |
Product Specific References | 1. Rao, M., W. Lee, and D. Conrad. 1987. J. Immunol. 138:1845.2. Cong Y.Z., Rabin E. and Wortis H.H. 1991. International Immunology. 3:467.3. Conrad DH. 1991. Monographs in Allergy. 29:9.4. Vercelli D.and Geha RS. 1989. Annals of Allergy. 63:4.5. Yu, P., Kosco-Vilbios, M., Richards, M., Kohler, G. and Lamers, M.C. 1994. Nature 369:753.6. Bonnefoy, J.-Y., Lecoanet-Henchoz, S., Aubry, J.P., Gauchat, J.F. and Graber, P. 1995. Current Opinions in Immunol. 7:355. |