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Antigenic Specificity | DVL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: DVL1 antibody detects endogenous levels of total DVL1. Function: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).Subunit Structure: Interacts with CXXC4. Interacts (via PDZ domain) with NXN (By similarity). Interacts with BRD7 and INVS. Interacts th |
Immunogen | Immunogen: A synthesized peptide derived from human DVL1 Subcellular Location: Cell Membrane. Cytoplasm, Cytosol. Cytoplasmic Vesicle. Localizes at the cell membrane upon interaction with frizzled family members. Predicted Cross Reactivity: Pig, Bovine, Horse, Sheep, Dog, Chicken Similarity: Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Dog (100%), Chicken (80%) |
Other Names | [Dishevelled 1; dishevelled 1 like; Dishevelled; Dishevelled dsh homolog 1; Dishevelled-1; Dishevelled1; DSH homolog 1; Dvl 1; Dvl; Dvl1; DVL1_HUMAN; DVL1L1; MGC54245; Segment polarity protein dishevelled homolog DVL 1; segment polarity protein dishevelled homolog DVL 1 like; Segment polarity protein dishevelled homolog DVL-1; Segment polarity protein dishevelled homolog DVL1] |
Gene, Accession # | [DVL1], Gene ID: 1855, NCBI: NP_001317240.1, UniProt: O14640 |
Catalog # | MBS9608124 |
Price | $240, $280 |
Order / More Info | DVL1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |