FANCD2 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | FANCD2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human FANCD2. Fanconi anemia (FA) is an autosomal recessive genetic disorder resulting in symptoms that include chromosomal breakage, bone marrow failure, hypersensitivity to DNA cross-linking agents (such as MMC), and a predisposition to cancer (1). FANCD2 is the gene product of one of at least six genes thought to contribute heterogeneously to FA (2). MMC treatment results in ubiquitination of FANCD2 on Lys561, converting the protein from a short form (FANCD2-S) to a monoubiquitinated or long (FANCD2-L) form that localizes to subnuclear foci at sites of DNA damage with BRCA1, Rad51, and NBS1 (3-5). Ionizing radiation, on the other hand, results in ATM-dependent phosphorylation of FANCD2 at Ser222 and Ser1404 resulting |
| Immunogen | Immunogen: A synthetic -peptide of human FANCD2 |
| Other Names | [FANCD2; FANCD2; FANCD2; FANCD2; DKFZp762A223; FA-D2; FA4; FACD; FAD; FAD2; FANCD; FLJ23826], [FANCD2; FANCD2; FA4; FAD; FACD; FAD2; FA-D2; FANCD; FACD; Protein FACD2] |
| Gene, Accession # | Gene ID: 2177, NCBI: NP_001018125.1, UniProt: Q9BXW9 |
| Catalog # | MBS125866 |
| Price | $275, $430 |
| Order / More Info | FANCD2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Alter, B.P. (1996) Am. J. Hematol. 53, 99-110. 2. Timmers, C. et al. (2001) Mol. Cell 7, 241-248. 3. Garcia-Higuera, I. et al. (2001) Mol. Cell 7, 249-262. 4. Taniguchi, T. et al. (2002) Cell 109, 459-472. 5. Nakanishi, K. et al. (2002) Nat. Cell Biol. 4, 913-920 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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