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Antigenic Specificity | BRCC45 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | BRCC45 Antibody: BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isofor |
Immunogen | Immunogen: BRCC45 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC45. Buffer: BRCC45 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [BRCC45; BRCC4; BRCC45; BRCA1-A complex subunit BRE; Brain and reproductive organ-expressed protein; brain and reproductive organ-expressed (TNFRSF1A modulator)], [BRE; BRE; BRCC4; BRCC45] |
Gene, Accession # | [BRE], Gene ID: 9577, NCBI: NP_004890, UniProt: Q9NXR7 |
Catalog # | MBS150821 |
Price | $375 |
Order / More Info | BRCC45 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |