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Antigenic Specificity | VWA5A |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 2.2mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decr |
Immunogen | Immunogen: Recombinant protein of human VWA5A Calculated Molecular Weight: 86kDa |
Other Names | [BCSC1; BCSC-1; LOH11CR2A] |
Gene, Accession # | [VWA5A], Gene ID: 4013, NCBI: O00534.2 |
Catalog # | MBS2525379 |
Price | $110, $150, $225 |
Order / More Info | VWA5A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |