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Antigenic Specificity | Prohibitin (Mitochondrial Marker) |
Clone | [PHB/3230] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2a, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a protein of 30kDa which is identified as Prohibitin, an evolutionarily conserved protein with homologues found in yeast to man. It is located in the inner membrane of mitochondria. Although prohibitin mRNA and protein expression occurs throughout the cell cycle, maximum levels are detected during the G1/S phase transition and minimum levels are seen in S phase and the G2/mitosis boundary. Prohibitin is located exclusively in the mitochondria with the highest concentration on the inner membrane. Prohibitin is an ideal mitochondrial marker. It shows antiproliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression. |
Immunogen | Immunogen: Recombinant human PHB protein fragment (aa167-261) (exact sequence is proprietary) |
Other Names | [Epididymis luminal protein 215; Epididymis secretory sperm binding protein Li 54e; HEL 215; HEL S 54e; PHB; PHB1; Prohibitin] |
Gene, Accession # | [PHB], Gene ID: 5245, NCBI: AAB21614.1, UniProt: P35232 |
Catalog # | MBS4381165 |
Price | $190, $340, $340 |
Order / More Info | Prohibitin (Mitochondrial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | McClung, J.K., et al. Gerontol. 1995, 30(2):99-124 |