UNC5B (Center) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | UNC5B (Center) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This UNC5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 507-541 amino acids from the Central region of human UNC5B. Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity. |
| Immunogen | n/a |
| Other Names | [Netrin receptor UNC5B; Protein unc-5 homolog 2; Protein unc-5 homolog B; p53-regulated receptor for death and life protein 1; UNC5B; P53RDL1; UNC5H2] |
| Gene, Accession # | [UNC5B], Gene ID: 219699, NCBI: NP_001231818.1, UniProt: Q8IZJ1 |
| Catalog # | MBS9208434 |
| Price | $165, $370 |
| Order / More Info | UNC5B (Center) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Komatsuzaki K.,et al.Biochem. Biophys. Res. Commun. 297:898-905(2002). Tanikawa C.,et al.Nat. Cell Biol. 5:216-223(2003). Clark H.F.,et al.Genome Res. 13:2265-2270(2003). Ota T.,et al.Nat. Genet. 36:40-45(2004). Deloukas P.,et al.Nature 429:375-381(2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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