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Antigenic Specificity | MDK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 21-143 of human MDK (NP 002382.1). |
Other Names | [MK; ARAP; NEGF2] |
Gene, Accession # | [MDK], Gene ID: 4192, NCBI: NP_001257480.1, UniProt: P21741 |
Catalog # | MBS8543975 |
Price | $280 |
Order / More Info | MDK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |