Human CD2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD2 |
| Clone | [SBCD2] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.5 mg, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cell surface molecule CD2 is a 45- to 58-kDa type I integral protein expressed on virtually all T lineage and NK cells. The extracellular domain of CD2 is composed by two Ig superfamily domains, of which the membrane-distal V- like domain is involved in the binding to the ligand. CD2 has different ligands in rodents (CD48) and humans (CD58), and the mechanisms of ligand binding are substantially different, as assessed by thermodynamic analysis. Nevertheless, engagement of CD2 to CD58 in humans, or to CD48 in rodents, facilitates adhesion between T cells and APC and is proposed to promote the formation of an optimal intercellular membrane spacing suitable for TCR recognition of a peptide Ag bound to MHC. |
| Immunogen | Host Note: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human CD2. |
| Other Names | [Mouse Human CD2; mab;; CD2; LFA2; lfa-2; t11; cd-2B], [CD2; SRBC] |
| Gene, Accession # | [CD2], Gene ID: 914, NCBI: NP_001758.2, UniProt: P06729 |
| Catalog # | MBS550090 |
| Price | $480, $775 |
| Order / More Info | Human CD2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • cd34, cd56 and CD2 are predictive of npm1 mutation, flt3-itd and their favorable prognosis combination in cytogenetically normal acute myeloid leukemia.Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 1576. • population pharmacokinetics of siplizumab (medi-507), a humanized anti-CD2 monoclonal antibody, in cancer patients.Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2670. • ex vivo il-2 expansion of cb-nk cells promotes synergistic lfa-1 and CD2 engagement at the nk cell lytic immune synapse; implications for adoptive cb-nk cell therapy in acute myeloid leukemia.Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 3029. • inhibition and activation by CD244 depends on CD2 and phospholipase c-1.J. Biol. Chem., Sep 2009; 284: 24725 - 24734. • lfa-1 and CD2 synergize for the erk1/2 activation in the natural killer (nk) cell immunological synapse.J. Biol. Chem., Aug 2009; 284: 21280 - 21287. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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