Edit |   |
Antigenic Specificity | LMNA |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3, 4). The cleavage of lamins results in nuclear disregulation and cell death (5, 6). |
Immunogen | Immunogen: Recombinant protein of human LMNA Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [LMNA; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; PRO1] |
Gene, Accession # | [LMNA], Gene ID: 4000, NCBI: NP_001244303.1, UniProt: P02545 |
Catalog # | MBS8502654 |
Price | $310 |
Order / More Info | LMNA Antibody from MYBIOSOURCE INC. |
Product Specific References | 21. Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23. 22. Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84. 23. Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93. 24. Orth, K. et al. (1996) J Biol Chem 271, 16443-6. 25. Oberhammer, F.A. et al. (1994) J Cell Biol 126, 827-37. 26. Rao, L. et al. (1996) J Cell Biol 135, 1441-55. |