LMNA Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityLMNA
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse, rat
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionLamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3, 4). The cleavage of lamins results in nuclear disregulation and cell death (5, 6).
ImmunogenImmunogen: Recombinant protein of human LMNA Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Other Names[LMNA; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; PRO1]
Gene, Accession #[LMNA], Gene ID: 4000, NCBI: NP_001244303.1, UniProt: P02545
Catalog #MBS8502654
Price$310
Order / More InfoLMNA Antibody from MYBIOSOURCE INC.
Product Specific References21. Gruenbaum, Y. et al. (2000) J Struct Biol 129, 313-23. 22. Yabuki, M. et al. (1999) Physiol Chem Phys Med NMR 31, 77-84. 23. Goldberg, M. et al. (1999) Crit Rev Eukaryot Gene Expr 9, 285-93. 24. Orth, K. et al. (1996) J Biol Chem 271, 16443-6. 25. Oberhammer, F.A. et al. (1994) J Cell Biol 126, 827-37. 26. Rao, L. et al. (1996) J Cell Biol 135, 1441-55.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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