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Antigenic Specificity | MYD88 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-309 of human MYD88 (NP 002459.2). |
Other Names | [MYD88D] |
Gene, Accession # | [MYD88], Gene ID: 4615, NCBI: NP_001166037.1, UniProt: Q99836 |
Catalog # | MBS8544109 |
Price | $280 |
Order / More Info | MYD88 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |