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Antigenic Specificity | Osteocalcin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | rat. |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for Osteocalcin (BGLAP) detection. Background: Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein found in bone and dentin. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A. It is mapped to 1q22. Osteocalcin may play a role in the body's metabolic regulation and is pro-osteoblastic, or bone-building. It acts as a hormone in the body, causing beta cellsin the pancreas to release more insulin, and at the same time directing fat cells to release the hormone adiponectin, which increases sensitivity to insulin. Also, it may play a role in male fertility. And it is found that picomolar amounts of osteocalcin affected insul |
Immunogen | Immunogen: E Coli-derived rat Osteocalcin recombinant protein (Position: Y50-V99). Rat Osteocalcin shares 80.9% and 68.9% amino acid (aa) sequence identity with human and mouse Osteocalcin, respectively. |
Other Names | [BGLAP; Bone Gla protein; ocn; OSTCN HUMAN; Osteocalcin; P04640; Osteocalcin; bone gamma-carboxyglutamate (gla) protein], [Bglap; Bglap; Bgp; Bgpr; Bgpra; Bglap2; Bglap2; BGP] |
Gene, Accession # | [BGLAP], Gene ID: 25295, NCBI: NP_038200.1, UniProt: P04640 |
Catalog # | MBS178420 |
Price | $315 |
Order / More Info | Osteocalcin Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Cancela L, Hsieh CL, Francke U, Price PA (September 1990). Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. J. Biol. Chem. 265 (25): 15040-8.2. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G (August 2007). Endocrine regulation of energy metabolism by the skeleton. Cell 130 (3): 456-69.3. Puchacz E, Lian JB, Stein GS, Wozney J, Huebner K, Croce C (May 1989). Chromosomal localization of the human osteocalcin gene. Endocrinology 124 (5): 2648-50. |