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Antigenic Specificity | Human IL-17A |
Clone | [BL168] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | fluorescein (FITC) conjugate |
Size | 20 tests, 50 tests, 100 tests |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-kappaB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity |
Immunogen | n/a |
Other Names | [CTLA8; IL17; CTLA-8; IL 17A] |
Gene, Accession # | [IL-17A], Gene ID: 3605, NCBI: NP_002181.1, UniProt: Q16552 |
Catalog # | MBS2559221 |
Price | $100, $125, $165 |
Order / More Info | Human IL-17A Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |