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Antigenic Specificity | SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) antibody recognizes mothers against decapentaplegic homolog 2 (SMAD2), when phosphorylated at serine 465 and serine 467 and mothers against decapentaplegic homolog 3 (SMAD3) when phosphorylated at serine 423 and serine 425. The SMAD protein family mediates transforming growth factor-beta (TGF-beta) signaling from the membrane to the nucleus (Attisano, L. & Wrana, J.L. 2002). SMAD2 is phosphorylated on serine 465 and serine 467 by TGF beta type I receptor (TbetaRI). This phosphorylation is essential for SMAD2's binding to SMAD4 and for the orchestration of TGF beta signaling (Abdollah, S. et al. 1997). The antibody also recognizes SMAD3 phosphorylated on Ser423 and Ser425 by homolog |
Immunogen | Immunogen: Phospho specific-peptide corresponding to residues surrounding serine 465/467 of human SMAD2 and serine 423/425 of human SMAD3 |
Other Names | [SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425)], [SMAD2; SMAD2; JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; MADH2; MADR2; MAD homolog 2; Mothers against DPP homolog 2; hMAD-2; SMAD 2; Smad2; hSMAD2] |
Gene, Accession # | [SMAD2/SMAD3], Gene ID: 4087, NCBI: NP_001003652.1, UniProt: Q15796 |
Catalog # | MBS225574 |
Price | $375 |
Order / More Info | SMAD2 (pSer465/pSer467)/SMAD3 (pSer423/pSer425) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |