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Antigenic Specificity | SOX2 (Embryonic Stem Cell Marker) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker. |
Immunogen | Immunogen: Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary) |
Other Names | [ANOP3; Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); SOX-2; SRY (sex determining region Y) box 2; SRY related HMG box 2; Transcription factor SOX-2; ysb] |
Gene, Accession # | [SOX2], Gene ID: 6657, NCBI: NP_003097.1, UniProt: P48431 |
Catalog # | MBS4381255 |
Price | $190, $340, $340 |
Order / More Info | SOX2 (Embryonic Stem Cell Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Laudet, V., et al, H. 1993. Nucleic Acids Res. 21: 2493-2501 |