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Antigenic Specificity | Human GFRA2 |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | unconjugated |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | GFRA2 is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRA2 is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are its binding ligand which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GDNF promotes the formation of a physical complex between GFRA/GDNFRa and the orphan tyrosin kinase receptor Ret, thereby inducing its tyrosine phosphorylation. The |
Immunogen | Immunogen: Recombinant Human GFRA2 protein Buffer: 0.2 mum filtered solution in PBS with 5% trehalose |
Other Names | [GDNF family receptor alpha-2 isoform c; GDNF family receptor alpha-2; GDNF family receptor alpha-2; GDNF family receptor alpha 2; GDNF receptor beta; GDNFR-beta; Neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; RET ligand 2; TGF-beta-related neurotrophic factor receptor 2] |
Gene, Accession # | [GFRA2 ], Gene ID: 2675 |
Catalog # | MBS2543936 |
Price | $215, $330, $500 |
Order / More Info | Human GFRA2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |