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Antigenic Specificity | Ep-CAM/CD326 (Extracellular Domain) (Epithelial Marker) |
Clone | [EGP40/826] |
Host Species | Mouse |
Reactive Species | humandoes not react with mouse or rat. |
Isotype | IgG1, kappa |
Format | CF488 conjugate |
Size | 0.5 mL |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes a 40-43kDa transmembrane epithelial glycoprotein, identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). Ep-CAM is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. It is also useful in distinguishing serous carcinomas of the ovary from mesothelioma. This epithelial antigen plays an important role as a tumor-cell marker in lymph nodes from patients with esophageal carcinoma otherwise classified as node-negative. Epithelial antigen has also been suggested as a discriminator between basal cell and baso-squamous carcinomas, and |
Immunogen | Immunogen: A synthetic peptide (around aa 20-60) from the N-terminus of human TACSTD1 protein |
Other Names | [Adenocarcinoma-associated Antigen; Cell Surface Glycoprotein Trop-1; EGP2; EGP314; EGP40; Epithelial Cell Adhesion Molecule; Epithelial Glycoprotein 314; ESA; KSA; TACD1; TROP1; Tumor-associated Calcium Signal Transducer 1 (TACSTD1)] |
Gene, Accession # | [Ep-CAM/CD326], Gene ID: 4072, NCBI: NP_002345.2, UniProt: P16422 |
Catalog # | MBS4381072 |
Price | $340 |
Order / More Info | Ep-CAM/CD326 (Extracellular Domain) (Epithelial Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Bjork, P., et al. 1993. Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glyco- protein recognized by the C215 Mouse monoclonal antibody. J. Biol. Chem. 268: 24232-24241. |